Daily Papers

Recent contrastive multimodal vision-language models like CLIP have demonstrated robust open-world semantic understanding, becoming the standard image backbones for vision-language applications due to their aligned latent space. However, this practice has left powerful unimodal encoders for both vision and language underutilized in multimodal applications which raises a key question: Is there a plausible way to connect unimodal backbones for zero-shot vision-language tasks? To this end, we propose a novel approach that aligns vision and language modalities using only projection layers on pretrained, frozen unimodal encoders. Our method exploits the high semantic similarity between embedding spaces of well-trained vision and language models. It involves selecting semantically similar encoders in the latent space, curating a concept-rich dataset of image-caption pairs, and training simple MLP projectors. We evaluated our approach on 12 zero-shot classification datasets and 2 image-text retrieval datasets. Our best model, utilizing DINOv2 and All-Roberta-Large text encoder, achieves 76\(\%\) accuracy on ImageNet with a 20-fold reduction in data and 65 fold reduction in compute requirements. The proposed framework enhances the accessibility of model development while enabling flexible adaptation across diverse scenarios, offering an efficient approach to building multimodal models by utilizing existing unimodal architectures. Code and datasets will be released soon.

The detection of hallucinations in multilingual scientific text generated by Large Language Models (LLMs) presents significant challenges for reliable AI systems. This paper describes our submission to the SHROOM-CAP 2025 shared task on scientific hallucination detection across 9 languages. Unlike most approaches that focus primarily on model architecture, we adopted a data-centric strategy that addressed the critical issue of training data scarcity and imbalance. We unify and balance five existing datasets to create a comprehensive training corpus of 124,821 samples (50% correct, 50% hallucinated), representing a 172x increase over the original SHROOM training data. Our approach fine-tuned XLM-RoBERTa-Large with 560 million parameters on this enhanced dataset, achieves competitive performance across all languages, including 2nd place in Gujarati (zero-shot language) with Factuality F1 of 0.5107, and rankings between 4th-6th place across the remaining 8 languages. Our results demonstrate that systematic data curation can significantly outperform architectural innovations alone, particularly for low-resource languages in zero-shot settings.

This work aims to build a text embedder that can capture characteristics of texts specified by user instructions. Despite its tremendous potential to deploy user-oriented embeddings, none of previous approaches provides a concrete solution for it. This paper offers a new viewpoint, which treats the instruction as a question about the input text and encodes the expected answers to obtain the representation accordingly. Intuitively, texts with the same (implicit) semantics would share similar answers following the instruction, thus leading to more similar embeddings. Specifically, we propose InBedder that instantiates this embed-via-answering idea by only fine-tuning language models on abstractive question answering tasks. InBedder demonstrates significantly improved instruction-following capabilities according to our proposed instruction awareness tests and instruction robustness tests, when applied to both large language models (LLMs) (e.g., llama-2-7b) and smaller encoder-based LMs (e.g., roberta-large). Additionally, our qualitative analysis of clustering outcomes, achieved by applying different instructions to the same corpus, demonstrates a high degree of interpretability.

We present GraPPa, an effective pre-training approach for table semantic parsing that learns a compositional inductive bias in the joint representations of textual and tabular data. We construct synthetic question-SQL pairs over high-quality tables via a synchronous context-free grammar (SCFG) induced from existing text-to-SQL datasets. We pre-train our model on the synthetic data using a novel text-schema linking objective that predicts the syntactic role of a table field in the SQL for each question-SQL pair. To maintain the model's ability to represent real-world data, we also include masked language modeling (MLM) over several existing table-and-language datasets to regularize the pre-training process. On four popular fully supervised and weakly supervised table semantic parsing benchmarks, GraPPa significantly outperforms RoBERTa-large as the feature representation layers and establishes new state-of-the-art results on all of them.

Reinforcement Learning from Human Feedback (RLHF) has emerged as a dominant approach for aligning LLM outputs with human preferences. Inspired by the success of RLHF, we study the performance of multiple algorithms that learn from feedback (Expert Iteration, Proximal Policy Optimization (PPO), Return-Conditioned RL) on improving LLM reasoning capabilities. We investigate both sparse and dense rewards provided to the LLM both heuristically and via a learned reward model. We additionally start from multiple model sizes and initializations both with and without supervised fine-tuning (SFT) data. Overall, we find all algorithms perform comparably, with Expert Iteration performing best in most cases. Surprisingly, we find the sample complexity of Expert Iteration is similar to that of PPO, requiring at most on the order of 10^6 samples to converge from a pretrained checkpoint. We investigate why this is the case, concluding that during RL training models fail to explore significantly beyond solutions already produced by SFT models. Additionally, we discuss a trade off between maj@1 and pass@96 metric performance during SFT training and how conversely RL training improves both simultaneously. We then conclude by discussing the implications of our findings for RLHF and the future role of RL in LLM fine-tuning.

We present MULTICONER V2, a dataset for fine-grained Named Entity Recognition covering 33 entity classes across 12 languages, in both monolingual and multilingual settings. This dataset aims to tackle the following practical challenges in NER: (i) effective handling of fine-grained classes that include complex entities like movie titles, and (ii) performance degradation due to noise generated from typing mistakes or OCR errors. The dataset is compiled from open resources like Wikipedia and Wikidata, and is publicly available. Evaluation based on the XLM-RoBERTa baseline highlights the unique challenges posed by MULTICONER V2: (i) the fine-grained taxonomy is challenging, where the scores are low with macro-F1=0.63 (across all languages), and (ii) the corruption strategy significantly impairs performance, with entity corruption resulting in 9% lower performance relative to non-entity corruptions across all languages. This highlights the greater impact of entity noise in contrast to context noise.

During the last two years there has been a plethora of large generative models such as ChatGPT or Stable Diffusion that have been published. Concretely, these models are able to perform tasks such as being a general question and answering system or automatically creating artistic images that are revolutionizing several sectors. Consequently, the implications that these generative models have in the industry and society are enormous, as several job positions may be transformed. For example, Generative AI is capable of transforming effectively and creatively texts to images, like the DALLE-2 model; text to 3D images, like the Dreamfusion model; images to text, like the Flamingo model; texts to video, like the Phenaki model; texts to audio, like the AudioLM model; texts to other texts, like ChatGPT; texts to code, like the Codex model; texts to scientific texts, like the Galactica model or even create algorithms like AlphaTensor. This work consists on an attempt to describe in a concise way the main models are sectors that are affected by generative AI and to provide a taxonomy of the main generative models published recently.

Large Multimodal Models (LMMs) exhibit major shortfalls when interpreting images and, by some measures, have poorer spatial cognition than small children or animals. Despite this, they attain high scores on many popular visual benchmarks, with headroom rapidly eroded by an ongoing surge of model progress. To address this, there is a pressing need for difficult benchmarks that remain relevant for longer. We take this idea to its limit by introducing ZeroBench-a lightweight visual reasoning benchmark that is entirely impossible for contemporary frontier LMMs. Our benchmark consists of 100 manually curated questions and 334 less difficult subquestions. We evaluate 20 LMMs on ZeroBench, all of which score 0.0%, and rigorously analyse the errors. To encourage progress in visual understanding, we publicly release ZeroBench.

The development of speech foundation models (SFMs) like Whisper and SeamlessM4T has significantly advanced the field of speech processing. However, their closed nature--with inaccessible training data and code--poses major reproducibility and fair evaluation challenges. While other domains have made substantial progress toward open science by developing fully transparent models trained on open-source (OS) code and data, similar efforts in speech remain limited. To fill this gap, we introduce FAMA, the first family of open science SFMs for English and Italian, trained on 150k+ hours of OS speech data. Moreover, we present a new dataset containing 16k hours of cleaned and pseudo-labeled speech for both languages. Results show that FAMA achieves competitive performance compared to existing SFMs while being up to 8 times faster. All artifacts, including code, datasets, and models, are released under OS-compliant licenses, promoting openness in speech technology research.

Modern optimization in experimental chemistry employs algorithmic search through black-box parameter spaces. Here we demonstrate that pre-trained knowledge in large language models (LLMs) fundamentally changes this paradigm. Using six fully enumerated categorical reaction datasets (768 - 5,684 experiments), we benchmark LLM-guided optimization (LLM-GO) against Bayesian optimization (BO) and random sampling. Frontier LLMs consistently match or exceed BO performance across five single-objective datasets, with advantages growing as parameter complexity increases and high-performing conditions become scarce (<5% of space). BO retains superiority only for explicit multi-objective trade-offs. To understand these contrasting behaviors, we introduce a topology-agnostic information theory framework quantifying sampling diversity throughout optimization campaigns. This analysis reveals that LLMs maintain systematically higher exploration entropy than BO across all datasets while achieving superior performance, with advantages most pronounced in solution-scarce parameter spaces where high-entropy exploration typically fails - suggesting that pre-trained domain knowledge enables more effective navigation of chemical parameter space rather than replacing structured exploration strategies. To enable transparent benchmarking and community validation, we release Iron Mind (https://gomes.andrew.cmu.edu/iron-mind), a no-code platform for side-by-side evaluation of human, algorithmic, and LLM optimization campaigns with public leaderboards and complete trajectories. Our findings establish that LLM-GO excels precisely where traditional methods struggle: complex categorical spaces requiring domain understanding rather than mathematical optimization.

The transformer architecture has revolutionized bioinformatics and driven progress in the understanding and prediction of the properties of biomolecules. Almost all research on large-scale biosequence transformers has focused on one domain at a time (single-omic), usually nucleotides or peptides. These models have seen incredible success in downstream tasks in each domain and have achieved particularly noteworthy breakthroughs in sequences of peptides and structural modeling. However, these single-omic models are naturally incapable of modeling multi-omic tasks, one of the most biologically critical being nucleotide-peptide interactions. We present our work training the first multi-omic nucleotide-peptide foundation models. We show that these multi-omic models (MOMs) can learn joint representations between various single-omic distributions that are emergently consistent with the Central Dogma of molecular biology, despite only being trained on unlabeled biosequences. We further demonstrate that MOMs can be fine-tuned to achieve state-of-the-art results on peptide-nucleotide interaction tasks, namely predicting the change in Gibbs free energy ({\Delta}G) of the binding interaction between a given oligonucleotide and peptide, as well as the effect on this binding interaction due to mutations in the oligonucleotide sequence ({\Delta}{\Delta}G). Remarkably, we show that multi-omic biosequence transformers emergently learn useful structural information without any prior structural training, allowing us to predict which peptide residues are most involved in the peptide-nucleotide binding interaction. Lastly, we provide evidence that multi-omic biosequence models are non-inferior to foundation models trained on single-omics distributions, suggesting a more generalized or foundational approach to building these models.

LLMs have seen rapid adoption in all domains. They need to be trained on high-end high-performance computing (HPC) infrastructures and ingest massive amounts of input data. Unsurprisingly, at such a large scale, unexpected events (e.g., failures of components, instability of the software, undesirable learning patterns, etc.), are frequent and typically impact the training in a negative fashion. Thus, LLMs need to be checkpointed frequently so that they can be rolled back to a stable state and subsequently fine-tuned. However, given the large sizes of LLMs, a straightforward checkpointing solution that directly writes the model parameters and optimizer state to persistent storage (e.g., a parallel file system), incurs significant I/O overheads. To address this challenge, in this paper we study how to reduce the I/O overheads for enabling fast and scalable checkpointing for LLMs that can be applied at high frequency (up to the granularity of individual iterations) without significant impact on the training process. Specifically, we introduce a lazy asynchronous multi-level approach that takes advantage of the fact that the tensors making up the model and optimizer state shards remain immutable for extended periods of time, which makes it possible to copy their content in the background with minimal interference during the training process. We evaluate our approach at scales of up to 180 GPUs using different model sizes, parallelism settings, and checkpointing frequencies. The results show up to 48times faster checkpointing and 2.2times faster end-to-end training runtime compared with the state-of-art checkpointing approaches.

We developed a benchmark set to assess the generalization of state-of-the-art large language models on problems beyond linguistic tasks and evaluate it on a systematic progression of GPT models (GPT-3.5, GPT-4, GPT-4o, GPT-4o-mini). Using simple games like Tic-Tac-Toe, Connect Four, Battleship, and a Shape Recognition Game, all encoded in ASCII, we test strategic capabilities and spatial reasoning, core abilities any artificial intelligence would need to master for solving problems in chemistry. To probe generalization, we introduce two new games for spatial logic: LEGO Connect Language (LCL) and Guess-the-SMILES (GtS), a operationally simple chemistry benchmark. Our results show that GPT models provide meaningful responses for several tasks but, generally, perform poorly. A systematic performance progression with increased model capabilities (GPT-3.5, GPT-4, GPT-4o) is only observed for 4 out of the 7 benchmark tasks. All models consistently struggle with Battleship, LCL, and GtS. This suggests that while GPT models can emulate conversational proficiency and basic rule comprehension, they have limited generalization with respect to strategy and spatial reasoning. Particularly poor performance is observed for interpreting molecular graphs when encoded in ASCII. The results provided by our open-source benchmark suite (https://github.com/BlueVelvetSackOfGoldPotatoes/child-play{ChildPlay GitHub Repository}) caution against claims of emergent intelligence in GPT models, which appear more specialized than general.

The rapid advancement of large language models (LLMs) has been paralleled by unprecedented increases in computational demands, with training costs for state-of-the-art models doubling every few months. Training models directly in low-precision arithmetic offers a solution, by improving both computational throughput and energy efficiency. Specifically, NVIDIA's recent Blackwell architecture facilitates extremely low-precision operations, specifically FP4 variants, promising substantial efficiency gains. Yet, current algorithms for training LLMs in FP4 precision face significant accuracy degradation and often rely on mixed-precision fallbacks. In this paper, we systematically investigate hardware-supported FP4 training and introduce Quartet, a new approach enabling accurate, end-to-end FP4 training with all the major computations (in e.g. linear layers) being performed in low precision. Through extensive evaluations on Llama-type models, we reveal a new low-precision scaling law that quantifies performance trade-offs across varying bit-widths and allows us to identify a "near-optimal" low-precision training technique in terms of accuracy-vs-computation, called Quartet. We implement Quartet using optimized CUDA kernels tailored for NVIDIA Blackwell GPUs, and show that it can achieve state-of-the-art accuracy for FP4 precision, successfully training billion-scale models. Our method demonstrates that fully FP4-based training is a competitive alternative to standard-precision and FP8 training. Our code is available at https://github.com/IST-DASLab/Quartet.

New capabilities in foundation models are owed in large part to massive, widely-sourced, and under-documented training data collections. Existing practices in data collection have led to challenges in documenting data transparency, tracing authenticity, verifying consent, privacy, representation, bias, copyright infringement, and the overall development of ethical and trustworthy foundation models. In response, regulation is emphasizing the need for training data transparency to understand foundation models' limitations. Based on a large-scale analysis of the foundation model training data landscape and existing solutions, we identify the missing infrastructure to facilitate responsible foundation model development practices. We examine the current shortcomings of common tools for tracing data authenticity, consent, and documentation, and outline how policymakers, developers, and data creators can facilitate responsible foundation model development by adopting universal data provenance standards.

Ensuring faithful interpretability in large language models is imperative for trustworthy and reliable AI. A key obstacle is self-repair, a phenomenon where networks compensate for reduced signal in one component by amplifying others, masking the true importance of the ablated component. While prior work attributes self-repair to layer normalization and back-up components that compensate for ablated components, we identify a novel form occurring within the attention mechanism, where softmax redistribution conceals the influence of important attention scores. This leads traditional ablation and gradient-based methods to underestimate the significance of all components contributing to these attention scores. We introduce Gradient Interaction Modifications (GIM), a technique that accounts for self-repair during backpropagation. Extensive experiments across multiple large language models (Gemma 2B/9B, LLAMA 1B/3B/8B, Qwen 1.5B/3B) and diverse tasks demonstrate that GIM significantly improves faithfulness over existing circuit identification and feature attribution methods. Our work is a significant step toward better understanding the inner mechanisms of LLMs, which is crucial for improving them and ensuring their safety. Our code is available at https://github.com/JoakimEdin/gim.

Recent advances have enabled LLM-powered AI agents to autonomously execute complex tasks by combining language model reasoning with tools, memory, and web access. But can these systems be trusted to follow deployment policies in realistic environments, especially under attack? To investigate, we ran the largest public red-teaming competition to date, targeting 22 frontier AI agents across 44 realistic deployment scenarios. Participants submitted 1.8 million prompt-injection attacks, with over 60,000 successfully eliciting policy violations such as unauthorized data access, illicit financial actions, and regulatory noncompliance. We use these results to build the Agent Red Teaming (ART) benchmark - a curated set of high-impact attacks - and evaluate it across 19 state-of-the-art models. Nearly all agents exhibit policy violations for most behaviors within 10-100 queries, with high attack transferability across models and tasks. Importantly, we find limited correlation between agent robustness and model size, capability, or inference-time compute, suggesting that additional defenses are needed against adversarial misuse. Our findings highlight critical and persistent vulnerabilities in today's AI agents. By releasing the ART benchmark and accompanying evaluation framework, we aim to support more rigorous security assessment and drive progress toward safer agent deployment.

While numerous frameworks have been developed to enhance the reasoning abilities of large language models (LLMs), there is a scarcity of methods that effectively balance the trade-off between cost and quality. In this paper, we introduce Fleet of Agents (FoA), a novel and intuitive yet principled framework utilizing LLMs as agents to navigate through dynamic tree searches, employing a genetic-type particle filtering approach. FoA spawns a multitude of agents, each exploring the search space autonomously, followed by a selection phase where resampling based on a heuristic value function optimizes the balance between exploration and exploitation. This mechanism enables dynamic branching, adapting the exploration strategy based on discovered solutions. We conduct extensive experiments on three benchmark tasks, ``Game of 24'', ``Mini-Crosswords'', and ``WebShop'', utilizing four different LLMs, ``GPT-3.5'', ``GPT-4'', ``LLaMA3.2-11B'', and ``LLaMA3.2-90B''. On average across all tasks and LLMs, FoA obtains a quality improvement of ~5% while requiring only ~40% of the cost of previous SOTA methods. Notably, our analyses reveal that (1) FoA achieves the best cost-quality trade-off among all benchmarked methods and (2) FoA + LLaMA3.2-11B surpasses the Llama3.2-90B model. FoA is publicly available at https://github.com/au-clan/FoA.

The internet contains a wealth of knowledge -- from the birthdays of historical figures to tutorials on how to code -- all of which may be learned by language models. However, there is a huge variability in the number of times a given piece of information appears on the web. In this paper, we study the relationship between the knowledge memorized by large language models and the information in their pre-training datasets. In particular, we show that a language model's ability to answer a fact-based question relates to how many documents associated with that question were seen during pre-training. We identify these relevant documents by entity linking pre-training datasets and counting documents that contain the same entities as a given question-answer pair. Our results demonstrate strong correlational and causal relationships between accuracy and relevant document count for numerous question answering datasets (e.g., TriviaQA), pre-training corpora (e.g., ROOTS), and model sizes (e.g., 176B parameters). Moreover, we find that while larger models are better at learning long-tail knowledge, we estimate that today's models must be scaled by many orders of magnitude to reach competitive QA performance on questions with little support in the pre-training data. Finally, we show that retrieval-augmentation can reduce the dependence on relevant document count, presenting a promising approach for capturing the long-tail.

Contrastive pretraining on parallel image-text data has attained great success in vision-language processing (VLP), as exemplified by CLIP and related methods. However, prior explorations tend to focus on general domains in the web. Biomedical images and text are rather different, but publicly available datasets are small and skew toward chest X-ray, thus severely limiting progress. In this paper, we conducted by far the largest study on biomedical VLP, using 15 million figure-caption pairs extracted from biomedical research articles in PubMed Central. Our dataset (PMC-15M) is two orders of magnitude larger than existing biomedical image-text datasets such as MIMIC-CXR, and spans a diverse range of biomedical images. The standard CLIP method is suboptimal for the biomedical domain. We propose BiomedCLIP with domain-specific adaptations tailored to biomedical VLP. We conducted extensive experiments and ablation studies on standard biomedical imaging tasks from retrieval to classification to visual question-answering (VQA). BiomedCLIP established new state of the art in a wide range of standard datasets, substantially outperformed prior VLP approaches. Surprisingly, BiomedCLIP even outperformed radiology-specific state-of-the-art models such as BioViL on radiology-specific tasks such as RSNA pneumonia detection, thus highlighting the utility in large-scale pretraining across all biomedical image types. We will release our models at https://aka.ms/biomedclip to facilitate future research in biomedical VLP.

Quantized training of Large Language Models (LLMs) remains an open challenge, as maintaining accuracy while performing all matrix multiplications in low precision has proven difficult. This is particularly the case when fine-tuning pre-trained models, which often already have large weight and activation outlier values that render quantized optimization difficult. We present HALO, a novel quantization-aware training approach for Transformers that enables accurate and efficient low-precision training by combining 1) strategic placement of Hadamard rotations in both forward and backward passes, to mitigate outliers during the low-precision computation, 2) FSDP integration for low-precision communication, and 3) high-performance kernel support. Our approach ensures that all large matrix multiplications during the forward and backward passes are executed in lower precision. Applied to LLAMA-family models, HALO achieves near-full-precision-equivalent results during fine-tuning on various tasks, while delivering up to 1.31x end-to-end speedup for full fine-tuning on RTX 4090 GPUs. Our method supports both standard and parameter-efficient fine-tuning (PEFT) methods, both backed by efficient kernel implementations. Our results demonstrate the first practical approach to fully quantized LLM fine-tuning that maintains accuracy in FP8 precision, while delivering performance benefits.

Large autoregressive generative models have emerged as the cornerstone for achieving the highest performance across several Natural Language Processing tasks. However, the urge to attain superior results has, at times, led to the premature replacement of carefully designed task-specific approaches without exhaustive experimentation. The Coreference Resolution task is no exception; all recent state-of-the-art solutions adopt large generative autoregressive models that outperform encoder-based discriminative systems. In this work,we challenge this recent trend by introducing Maverick, a carefully designed - yet simple - pipeline, which enables running a state-of-the-art Coreference Resolution system within the constraints of an academic budget, outperforming models with up to 13 billion parameters with as few as 500 million parameters. Maverick achieves state-of-the-art performance on the CoNLL-2012 benchmark, training with up to 0.006x the memory resources and obtaining a 170x faster inference compared to previous state-of-the-art systems. We extensively validate the robustness of the Maverick framework with an array of diverse experiments, reporting improvements over prior systems in data-scarce, long-document, and out-of-domain settings. We release our code and models for research purposes at https://github.com/SapienzaNLP/maverick-coref.

Poisoning attacks can compromise the safety of large language models (LLMs) by injecting malicious documents into their training data. Existing work has studied pretraining poisoning assuming adversaries control a percentage of the training corpus. However, for large models, even small percentages translate to impractically large amounts of data. This work demonstrates for the first time that poisoning attacks instead require a near-constant number of documents regardless of dataset size. We conduct the largest pretraining poisoning experiments to date, pretraining models from 600M to 13B parameters on chinchilla-optimal datasets (6B to 260B tokens). We find that 250 poisoned documents similarly compromise models across all model and dataset sizes, despite the largest models training on more than 20 times more clean data. We also run smaller-scale experiments to ablate factors that could influence attack success, including broader ratios of poisoned to clean data and non-random distributions of poisoned samples. Finally, we demonstrate the same dynamics for poisoning during fine-tuning. Altogether, our results suggest that injecting backdoors through data poisoning may be easier for large models than previously believed as the number of poisons required does not scale up with model size, highlighting the need for more research on defences to mitigate this risk in future models.

As large language models (LLMs) become more capable and agentic, the requirement for trust in their outputs grows significantly, yet at the same time concerns have been mounting that models may learn to lie in pursuit of their goals. To address these concerns, a body of work has emerged around the notion of "honesty" in LLMs, along with interventions aimed at mitigating deceptive behaviors. However, evaluations of honesty are currently highly limited, with no benchmark combining large scale and applicability to all models. Moreover, many benchmarks claiming to measure honesty in fact simply measure accuracy--the correctness of a model's beliefs--in disguise. In this work, we introduce a large-scale human-collected dataset for measuring honesty directly, allowing us to disentangle accuracy from honesty for the first time. Across a diverse set of LLMs, we find that while larger models obtain higher accuracy on our benchmark, they do not become more honest. Surprisingly, while most frontier LLMs obtain high scores on truthfulness benchmarks, we find a substantial propensity in frontier LLMs to lie when pressured to do so, resulting in low honesty scores on our benchmark. We find that simple methods, such as representation engineering interventions, can improve honesty. These results underscore the growing need for robust evaluations and effective interventions to ensure LLMs remain trustworthy.

Today's AI systems have human-designed, fixed architectures and cannot autonomously and continuously improve themselves. The advance of AI could itself be automated. If done safely, that would accelerate AI development and allow us to reap its benefits much sooner. Meta-learning can automate the discovery of novel algorithms, but is limited by first-order improvements and the human design of a suitable search space. The G\"odel machine proposed a theoretical alternative: a self-improving AI that repeatedly modifies itself in a provably beneficial manner. Unfortunately, proving that most changes are net beneficial is impossible in practice. We introduce the Darwin G\"odel Machine (DGM), a self-improving system that iteratively modifies its own code (thereby also improving its ability to modify its own codebase) and empirically validates each change using coding benchmarks. Inspired by Darwinian evolution and open-endedness research, the DGM maintains an archive of generated coding agents. It grows the archive by sampling an agent from it and using a foundation model to create a new, interesting, version of the sampled agent. This open-ended exploration forms a growing tree of diverse, high-quality agents and allows the parallel exploration of many different paths through the search space. Empirically, the DGM automatically improves its coding capabilities (e.g., better code editing tools, long-context window management, peer-review mechanisms), increasing performance on SWE-bench from 20.0% to 50.0%, and on Polyglot from 14.2% to 30.7%. Furthermore, the DGM significantly outperforms baselines without self-improvement or open-ended exploration. All experiments were done with safety precautions (e.g., sandboxing, human oversight). The DGM is a significant step toward self-improving AI, capable of gathering its own stepping stones along paths that unfold into endless innovation.

AI is increasingly playing a pivotal role in transforming how scientific discoveries are made. We introduce The AI Scientist-v2, an end-to-end agentic system capable of producing the first entirely AI generated peer-review-accepted workshop paper. This system iteratively formulates scientific hypotheses, designs and executes experiments, analyzes and visualizes data, and autonomously authors scientific manuscripts. Compared to its predecessor (v1, Lu et al., 2024 arXiv:2408.06292), The AI Scientist-v2 eliminates the reliance on human-authored code templates, generalizes effectively across diverse machine learning domains, and leverages a novel progressive agentic tree-search methodology managed by a dedicated experiment manager agent. Additionally, we enhance the AI reviewer component by integrating a Vision-Language Model (VLM) feedback loop for iterative refinement of content and aesthetics of the figures. We evaluated The AI Scientist-v2 by submitting three fully autonomous manuscripts to a peer-reviewed ICLR workshop. Notably, one manuscript achieved high enough scores to exceed the average human acceptance threshold, marking the first instance of a fully AI-generated paper successfully navigating a peer review. This accomplishment highlights the growing capability of AI in conducting all aspects of scientific research. We anticipate that further advancements in autonomous scientific discovery technologies will profoundly impact human knowledge generation, enabling unprecedented scalability in research productivity and significantly accelerating scientific breakthroughs, greatly benefiting society at large. We have open-sourced the code at https://github.com/SakanaAI/AI-Scientist-v2 to foster the future development of this transformative technology. We also discuss the role of AI in science, including AI safety.

Benchmarks play an important role in the development of machine learning algorithms. For example, research in reinforcement learning (RL) has been heavily influenced by available environments and benchmarks. However, RL environments are traditionally run on the CPU, limiting their scalability with typical academic compute. Recent advancements in JAX have enabled the wider use of hardware acceleration to overcome these computational hurdles, enabling massively parallel RL training pipelines and environments. This is particularly useful for multi-agent reinforcement learning (MARL) research. First of all, multiple agents must be considered at each environment step, adding computational burden, and secondly, the sample complexity is increased due to non-stationarity, decentralised partial observability, or other MARL challenges. In this paper, we present JaxMARL, the first open-source code base that combines ease-of-use with GPU enabled efficiency, and supports a large number of commonly used MARL environments as well as popular baseline algorithms. When considering wall clock time, our experiments show that per-run our JAX-based training pipeline is up to 12500x faster than existing approaches. This enables efficient and thorough evaluations, with the potential to alleviate the evaluation crisis of the field. We also introduce and benchmark SMAX, a vectorised, simplified version of the popular StarCraft Multi-Agent Challenge, which removes the need to run the StarCraft II game engine. This not only enables GPU acceleration, but also provides a more flexible MARL environment, unlocking the potential for self-play, meta-learning, and other future applications in MARL. We provide code at https://github.com/flairox/jaxmarl.

We present the findings of "The Alzheimer's Disease Prediction Of Longitudinal Evolution" (TADPOLE) Challenge, which compared the performance of 92 algorithms from 33 international teams at predicting the future trajectory of 219 individuals at risk of Alzheimer's disease. Challenge participants were required to make a prediction, for each month of a 5-year future time period, of three key outcomes: clinical diagnosis, Alzheimer's Disease Assessment Scale Cognitive Subdomain (ADAS-Cog13), and total volume of the ventricles. The methods used by challenge participants included multivariate linear regression, machine learning methods such as support vector machines and deep neural networks, as well as disease progression models. No single submission was best at predicting all three outcomes. For clinical diagnosis and ventricle volume prediction, the best algorithms strongly outperform simple baselines in predictive ability. However, for ADAS-Cog13 no single submitted prediction method was significantly better than random guesswork. Two ensemble methods based on taking the mean and median over all predictions, obtained top scores on almost all tasks. Better than average performance at diagnosis prediction was generally associated with the additional inclusion of features from cerebrospinal fluid (CSF) samples and diffusion tensor imaging (DTI). On the other hand, better performance at ventricle volume prediction was associated with inclusion of summary statistics, such as the slope or maxima/minima of biomarkers. TADPOLE's unique results suggest that current prediction algorithms provide sufficient accuracy to exploit biomarkers related to clinical diagnosis and ventricle volume, for cohort refinement in clinical trials for Alzheimer's disease. However, results call into question the usage of cognitive test scores for patient selection and as a primary endpoint in clinical trials.